Faculty Member, PhD

Özlem Ulucan Açan

+90 212 311 7052

Santralistanbul / EN1-108


  • PhD, 2015. Center for Bioinformatics, Saarland University, Saarbruecken, Germany. 
  • MSs, 2009. Computational Sciences and Engineering, Koc University, Istanbul, Turkey. 
  • BSc, 2007. Molecular Biology and Genetics, Istanbul University, Istanbul, Turkey. 


  • BIOE 341 Bioinformatics
  • ENGR 411 Statistical Learning
  • ENGR 240 Probability and Statistics for Engineers and Scientists 
  • BIOE 340 Modeling and Simulation in Bioengineering
  • BIOE 348 Physiology

Areas of Interest

  • Biomolecular Interactions
  • Computer-aided Drug Design
  • Functional Genomics
  • Statistical Leaning and Data Analysis

Rewards and Achievements

  • Socrates/Erasmus Program Scholarship, 2006.
  • TUBİTAK National Scholarship Program for Graduate Students, 2007-2009.
  • 09.2007 - 09.2009 Koc University Ful Scholarship, 2007-2009.

Other Information


  1. Shanak, S., Ulucan, O. and Helms V., Methylation-targeted specificity of the DNA binding proteins R.DpnI and MeCP2 studied by molecular dynamics simulations, J. Mol. Model, 2017, 23, 152.
  2. Ulucan, O., Helms V., How hydrophilic proteins form nonspecific complexes, J. Phys. Chem. B, 2015, 119 (33), 10524–10530 [EF: 3.177.
  3. Hochscherf, J., Lindenblatt, D., Steinkrüger, M., Yoo, E., Ulucan, Ö., Herzig, S., Issinger, O.-G., Helms, V., Götz, C., Neundorf, I., Niefind, K., Pietsch, M., Development of a high-throughput screening-compatible assay to identify inhibitors of the CK2α/CK2β interaction, Analytical Biochemistry, 2014, 468, 4-14.
  4. Ulucan O, Jaitly T, Helms V., Energetics of Hydrophilic Protein-Protein Association and the Role of Water, JCTC, 2014, 10 (8), 3512–3524.
  5. Tretter T, Pereira FP, Ulucan O, Helms V, Alan S, Kalies KU, Romisch K., ERAD and protein import defects in a sec61 mutant lacking ER-lumenal loop7, BMC Cell Biology, 2013, 14, 56.
  6. Ulucan O, Eyrisch S, and Helms V., Druggability of Dynamic Protein-protein Interfaces, Curr Farm Des, 2012, 18(30), 4599-4606.
  7. Walter P, Ulucan O, Metzger J, Helms V., Bioinformatics of Protein-Protein Interfaces and Small Molecule Effectors, Current Bioinformatics, 2012, 7(2), 159-172.
  8. Schäuble N, Lang S, Jung M, Cappel S, Shorr S, Ulucan Ö, Linxweiler J, Dudek J, Blum R, Helms V, Paton AW, Paton JC, Cavalié A, Zimmerman R., BiP-mediated closing of Sec61 channel limits Ca2+ leakage from ER. EMBO J, 2012, 31(15), 3282–3296.
  9. Ulucan O, Keskin O, Erman B., Gursoy A., A comparative Molecular Dynamics Study of Methylation State Specificity of JMJD2A, PLoS ONE, 2011, 6(9): e24664.